Description

13-cis-Retinol is a geometric isomer of Vitamin A (Retinol) with significant biological activity. This compound is a critical intermediate and reference standard in the research and development of pharmaceuticals and nutraceuticals. It is primarily utilized by manufacturers and R&D laboratories in the pharmaceutical, cosmetic, and advanced nutritional supplement industries for its role in cell differentiation and growth regulation.

Application

• Pharmaceutical Intermediate: Serves as a key starting material or intermediate in the synthesis of retinoid-based drugs targeting dermatological conditions and certain cancers.
• Analytical Reference Standard: Used as a high-purity standard in HPLC, LC-MS, and other analytical methods for quality control and research quantification.
• Nutraceutical Research: Employed in the development and study of advanced vitamin A formulations and pro-vitamin supplements.
• Cosmetic & Dermatological R&D: Investigated for its potential efficacy in anti-aging, skin-repair, and acne treatment formulations at the research stage.
• Biochemical Research: Used in studies of visual cycle biochemistry, cellular signaling, and gene regulation mediated by retinoids.

Basic Information

Product Name	13-cis-Retinol
CAS No.	2052-63-3
Molecular Formula	C₂₀H₃₀O
Molecular Weight	286.45 g/mol
Synonyms	13-cis-Vitamin A; (13Z)-Retinol; 13-Z-Retinol; Neovitamin A; Isotretinoin Alcohol; 13-cis-Retinol, Vitamin A Alcohol; all-trans-Retinol isomer; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol (13-cis)
EINECS	218-129-8

Quality Control

Our 13-cis-Retinol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by IR and NMR, purity assessment by HPLC, and impurity profiling to ensure it meets stringent specifications for research and production use. Certificates of Analysis (COA) detailing all test results are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C (refrigerated) or -20°C for extended periods. The container should be kept in a cool, dry, and well-ventilated area away from oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or oil
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
all-trans-Retinol (HPLC)	≤ 3.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solvent Residues (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.