Description

(R)-tert-Butyl 2-(Aminomethyl)Morpholine-4-Carboxylate Acetate is a high-purity chiral building block and intermediate of significant importance in modern synthetic chemistry. Its value lies in its role as a key precursor for the synthesis of complex, biologically active molecules, particularly in the pharmaceutical sector. This compound is essential for research and development chemists and process scale-up teams working in pharmaceutical development, agrochemical research, and advanced material science.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Synthesis: Used as a ligand or organocatalyst precursor in enantioselective reactions to create optically pure compounds.
• Peptidomimetics & Bioactive Molecule Construction: Serves as a constrained morpholine scaffold for designing protease inhibitors and other receptor-targeted molecules.
• Agrochemical Research: Employed in the development of novel, chiral herbicides and fungicides with improved efficacy and environmental profiles.
• Chemical Biology & Proteomics: Useful as a tagging or linking agent for probe development and studying biological pathways.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring high enantiomeric purity and reliable supply.

Basic Information

Product Name	(R)-tert-Butyl 2-(Aminomethyl)Morpholine-4-Carboxylate Acetate
CAS No.	1998701-09-9
Molecular Formula	C12H24N2O4 • C2H4O2 (or C14H28N2O6)
Molecular Weight	320.38 g/mol (for acetate salt)
Synonyms	(R)-tert-Butyl 2-(aminomethyl)morpholine-4-carboxylate acetate salt; (R)-N-Boc-2-(aminomethyl)morpholine acetate; (2R)-2-(Aminomethyl)-4-[(1,1-dimethylethoxy)carbonyl]morpholine acetate; tert-Butyl (R)-2-(aminomethyl)morpholine-4-carboxylate acetic acid salt; (R)-2-(Aminomethyl)-N-Boc-morpholine acetate; Boc-(R)-2-Aminomethyl-morpholine AcOH salt; 1998701-09-9; (S)-enantiomer is CAS 1260607-92-6
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 2-(Aminomethyl)Morpholine-4-Carboxylate Acetate is manufactured under controlled conditions to ensure batch-to-batch consistency and high chemical purity. Quality is assured through rigorous analytical testing, including HPLC for assay and enantiomeric excess, and NMR for structural confirmation. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided with each shipment to support your GMP or research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.