Description

(S)-1-Isopropyl-3-Methyl-Piperazine Dihydrochloride is a high-purity chiral piperazine derivative, a critical building block in modern pharmaceutical synthesis. Its value lies in its role as a versatile intermediate for constructing complex molecules with specific stereochemistry, essential for developing active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and production of novel therapeutics, particularly in areas requiring precise chiral control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and antiviral therapies.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to introduce the (S)-configured piperazine moiety into target molecules.
• API Development: Serves as a foundational building block in the synthesis of potential Active Pharmaceutical Ingredients (APIs) requiring a specific stereochemical orientation for optimal biological activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of chiral piperazine scaffolds on drug potency and selectivity.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for pilot and commercial-scale pharmaceutical manufacturing.
• Reference Standard: Can serve as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(S)-1-Isopropyl-3-Methyl-Piperazine Dihydrochloride
CAS No.	1965314-72-0
Molecular Formula	C8H20Cl2N2
Molecular Weight	215.16 g/mol
Synonyms	(S)-1-Isopropyl-3-methylpiperazine dihydrochloride; (3S)-1-Isopropyl-3-methylpiperazine dihydrochloride; (S)-1-(1-Methylethyl)-3-methylpiperazine dihydrochloride; (S)-3-Methyl-1-(propan-2-yl)piperazine dihydrochloride; (S)-1-Isopropyl-3-methylpiperazine hydrochloride (1:2); Piperazine, 1-(1-methylethyl)-3-methyl-, (3S)-, dihydrochloride
EINECS	Contact for details

Quality Control

Our (S)-1-Isopropyl-3-Methyl-Piperazine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.