Description

(R)-Methyl-Piperazin-2-One Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its defined stereochemistry is critical for the development of enantiomerically pure active pharmaceutical ingredients (APIs) and advanced fine chemicals. This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for process development and scale-up.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and oncology drug candidates.
• Asymmetric Synthesis: Serves as a versatile precursor for constructing complex molecular architectures requiring the (R)-configured piperazinone scaffold.
• Agrochemical Research: Used in the development of enantioselective pesticides and herbicides where specific chirality impacts biological activity.
• Chemical Biology & Proteomics: Employed as a specialty reagent for designing enzyme inhibitors, probes, and molecular tools.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis projects.
• Academic & Industrial R&D: A valuable compound for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	(R)-Methyl-Piperazin-2-One Hydrochloride
CAS No.	1965314-69-5
Molecular Formula	C5H11ClN2O
Molecular Weight	150.61 g/mol
Synonyms	(R)-1-Methylpiperazin-2-one hydrochloride; (R)-1-Methyl-2-piperazinone hydrochloride; (R)-N-Methyl-2-piperazinone hydrochloride; (3R)-1-Methyl-3,4-dihydro-2H-pyrazin-2-one hydrochloride; (R)-Methylpiperazinone HCl; (R)-MPO HCl; 1965314-69-5
EINECS	Contact for details

Quality Control

Our (R)-Methyl-Piperazin-2-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.