Description

(R)-1-Isopropyl-3-Methyl-Piperazine Dihydrochloride CAS NO 1965314-63-9 is a high-purity chiral piperazine derivative, specifically the (R)-enantiomer, supplied as a stable dihydrochloride salt. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, offering precise stereochemical control for the development of novel active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, including central nervous system (CNS) drugs and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new Active Pharmaceutical Ingredients (APIs), particularly for neurological and psychiatric targets.
• Asymmetric Synthesis: Used as a chiral ligand or auxiliary to induce stereoselectivity in catalytic reactions and complex molecule construction.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization campaigns to explore novel chemical space.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and commercial route development for chiral drugs.
• Chemical Biology: Can be incorporated into molecular probes for studying biological pathways and target engagement.
• Custom Synthesis: A foundational component for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	(R)-1-Isopropyl-3-Methyl-Piperazine Dihydrochloride
CAS No.	1965314-63-9
Molecular Formula	C8H20Cl2N2
Molecular Weight	215.16 g/mol
Synonyms	(R)-1-Isopropyl-3-methylpiperazine dihydrochloride; (R)-1-(Isopropyl)-3-methylpiperazine dihydrochloride; (R)-1-(1-Methylethyl)-3-methylpiperazine dihydrochloride; (R)-3-Methyl-1-(propan-2-yl)piperazine dihydrochloride; (R)-1-Isopropyl-3-methylpiperazine hydrochloride (1:2); (R)-1-Isopropyl-3-methyl-piperazine dihydrochloride; (R)-1-(Isopropyl)-3-methyl-piperazine dihydrochloride; (R)-1-Isopropyl-3-methylpiperazine 2HCl
EINECS	Contact for details

Quality Control

Our (R)-1-Isopropyl-3-Methyl-Piperazine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.