Description

(R)-tert-Butyl 2-(4-Bromophenyl)-6-Oxopiperidine-1-Carboxylate is a high-purity chiral piperidinone derivative, serving as a critical synthetic intermediate in advanced pharmaceutical research and development. Its value lies in providing a versatile, enantiomerically pure scaffold for constructing complex bioactive molecules, particularly in the synthesis of targeted therapeutics. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries, where it is used to develop new drug candidates with improved efficacy and safety profiles.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and oncology research.
• Chiral Auxiliary/Synthon: Utilized in asymmetric synthesis to introduce the (R)-configured stereocenter into more complex molecular architectures.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and lead optimization for new drug discovery programs.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scale-up and route development for potential clinical candidates.
• Reference Standard: Used as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	(R)-tert-Butyl 2-(4-Bromophenyl)-6-Oxopiperidine-1-Carboxylate
CAS No.	1956436-71-7
Molecular Formula	C16H20BrNO3
Molecular Weight	354.24 g/mol
Synonyms	1-Boc-2-(4-bromophenyl)-6-piperidinone (R-enantiomer); (R)-1-(tert-Butoxycarbonyl)-2-(4-bromophenyl)piperidin-6-one; (R)-N-Boc-2-(4-bromophenyl)-6-oxopiperidine; (R)-tert-Butyl 2-(4-bromophenyl)-6-oxo-1-piperidinecarboxylate; (R)-2-(4-Bromophenyl)-6-oxopiperidine-1-carboxylic acid tert-butyl ester; (R)-Boc-2-(4-Bromophenyl)-6-piperidone
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 2-(4-Bromophenyl)-6-Oxopiperidine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and assays for chemical purity and residual solvents. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.