Description

cis-tert-Butyl 3-Hydroxy-3,4-Dimethylpiperidine-1-Carboxylate (Wx641183) is a high-purity, protected piperidine derivative serving as a critical chiral building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, offering precise stereochemical control essential for developing active pharmaceutical ingredients (APIs) and fine chemicals. Pharmaceutical R&D laboratories and fine chemical manufacturers need it for the synthesis of novel therapeutic candidates, particularly in central nervous system (CNS) and metabolic disorder research, where its specific stereochemistry is a key design feature.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly for neurological and psychiatric applications.
• Asymmetric Synthesis: Utilized as a stereodefined building block for constructing complex molecules with high enantiomeric purity in medicinal chemistry.
• Ligand and Catalyst Development: Serves as a precursor for nitrogen-containing ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Agrochemical Research: Employed in the synthesis of advanced, stereospecific crop protection agents and herbicides.
• Academic & Industrial R&D: Used in chemical research for studying reaction mechanisms and developing new synthetic methodologies involving protected amino alcohols.
• Fine Chemical Production: Integral to the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring specific chiral centers.

Basic Information

Product Name	cis-tert-Butyl 3-Hydroxy-3,4-Dimethylpiperidine-1-Carboxylate (Wx641183)
CAS No.	1956379-68-2
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	1-Boc-3-hydroxy-3,4-dimethylpiperidine (cis); tert-Butyl 3-hydroxy-3,4-dimethylpiperidine-1-carboxylate; (3R,4S)-tert-Butyl 3-hydroxy-3,4-dimethylpiperidine-1-carboxylate; (3S,4R)-tert-Butyl 3-hydroxy-3,4-dimethylpiperidine-1-carboxylate; 3,4-Dimethyl-3-hydroxypiperidine-1-carboxylic acid tert-butyl ester; WX-641183; BOC-3-Hydroxy-3,4-dimethylpiperidine; 1-N-Boc-3-hydroxy-3,4-dimethylpiperidine
EINECS	Contact for details

Quality Control

Our cis-tert-Butyl 3-Hydroxy-3,4-Dimethylpiperidine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.