Description

(1R,2R,4R)-2-Amino-1,7,7-Trimethylbicyclo[2.2.1]heptane-2-carboxylic acid hydrochloride is a high-purity, stereochemically defined chiral building block essential for advanced organic synthesis. This compound matters as a critical intermediate for constructing complex molecules with precise three-dimensional architecture, enabling the development of novel pharmaceuticals and bioactive compounds. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Peptidomimetics & Bioactive Molecule Synthesis: Used to incorporate constrained, rigid bicyclic amino acid motifs into peptides and pseudopeptides to enhance metabolic stability and receptor selectivity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing novel chiral ligands and organocatalysts.
• Chemical Biology & Proteomics: Employed in the design and synthesis of chemical probes and activity-based protein profiling (ABPP) reagents.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and for exploring new synthetic routes to complex natural products.

Basic Information

Product Name	(1R,2R,4R)-2-Amino-1,7,7-Trimethylbicyclo[2.2.1]heptane-2-Carboxylic Acid Hydrochloride
CAS No.	1955474-97-1
Molecular Formula	C11H20ClNO2
Molecular Weight	233.73 g/mol
Synonyms	(1R,2R,4R)-2-Amino-2-carboxy-1,7,7-trimethylnorbornane hydrochloride; (1R,2R,4R)-1-Amino-3,3-dimethyl-2-norbornanecarboxylic acid hydrochloride; endo-(1R,2R,4R)-2-Amino-1,7,7-trimethylbicyclo[2.2.1]heptane-2-carboxylic acid HCl; (1R,2R,4R)-2-Amino-1,7,7-trimethyl-2-norbornanecarboxylic acid hydrochloride; Chiral Bicyclic Amino Acid Hydrochloride; (1R,2R,4R)-2-Aminocamphoric acid hydrochloride derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized and released with a comprehensive Certificate of Analysis (COA) to guarantee identity, purity, and stereochemical integrity. We adhere to strict in-process controls and final release specifications typical for advanced pharmaceutical intermediates. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.