Description

(1R)-1-(Pyrazin-2-Yl)Ethan-1-Amine Dihydrochloride is a high-purity chiral amine derivative, specifically the dihydrochloride salt of the (R)-enantiomer. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, offering precise stereochemical control for the development of novel active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs to introduce specific stereochemistry into molecular scaffolds.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Process Chemistry & Scale-Up: Serves as a defined starting material or intermediate in the development and optimization of scalable synthetic routes under Good Manufacturing Practice (GMP) guidelines.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds or molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	(1R)-1-(Pyrazin-2-Yl)Ethan-1-Amine Dihydrochloride
CAS No.	1955474-33-5
Molecular Formula	C6H10N3Cl2
Molecular Weight	195.07 g/mol
Synonyms	(R)-1-(Pyrazin-2-yl)ethan-1-amine dihydrochloride; (1R)-1-(2-Pyrazinyl)ethylamine dihydrochloride; (R)-1-(Pyrazin-2-yl)ethylamine dihydrochloride; (R)-α-Methyl-2-pyrazinemethanamine dihydrochloride; (R)-2-(1-Aminoethyl)pyrazine dihydrochloride; (R)-Ampyrazine dihydrochloride; (R)-P2EA dihydrochloride
EINECS	Contact for details

Quality Control

Our (1R)-1-(Pyrazin-2-Yl)Ethan-1-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets stringent specifications for research and development use. A detailed Certificate of Analysis (COA) providing identity, purity (assay), chiral purity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.