Description

(1S)-1-(Pyrazin-2-Yl)Ethan-1-Amine Dihydrochloride is a high-purity chiral amine building block and pharmaceutical intermediate. This compound is critical for the research and development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring stereochemical control. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex molecules for therapeutic applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates, especially for central nervous system (CNS) and antiviral targets.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing pyrazine-containing compound libraries for high-throughput screening (HTS).
• API Development: Integral in the process development and scale-up of new chemical entities (NCEs) requiring this specific stereochemistry.
• Bioconjugation: The amine functionality allows for use in linker chemistry for antibody-drug conjugates (ADCs) or other bioconjugation strategies.
• Chemical Biology Probes: Used in the development of molecular probes to study biological pathways and enzyme functions.

Basic Information

Product Name	(1S)-1-(Pyrazin-2-Yl)Ethan-1-Amine Dihydrochloride
CAS No.	1955473-78-5
Molecular Formula	C6H10N3Cl2
Molecular Weight	195.07 g/mol
Synonyms	(S)-1-(Pyrazin-2-yl)ethan-1-amine dihydrochloride; (1S)-1-(2-Pyrazinyl)ethylamine dihydrochloride; (S)-(-)-1-(Pyrazin-2-yl)ethylamine hydrochloride; (S)-1-(2-Pyrazinyl)ethylamine hydrochloride; (S)-α-Methyl-2-pyrazinemethanamine dihydrochloride; (S)-1-Pyrazin-2-ylethylamine dihydrochloride; (S)-2-(1-Aminoethyl)pyrazine dihydrochloride
EINECS	Contact for details

Quality Control

Our (1S)-1-(Pyrazin-2-Yl)Ethan-1-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.