Description

(2R,6S)-4-tert-Butyl 2-Methyl 6-(Hydroxymethyl)Morpholine-2,4-Dicarboxylate is a high-purity, stereochemically defined morpholine derivative used as a critical chiral building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures with precise stereochemical control, which is essential for developing active pharmaceutical ingredients (APIs) and other fine chemicals. Pharmaceutical R&D teams and fine chemical manufacturers need this high-value intermediate to produce novel therapeutics, particularly in areas like protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly for antiviral and anticancer therapies.
• Protease Inhibitor Development: Serves as a core scaffold or precursor in the design and synthesis of novel protease inhibitor molecules.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block to introduce stereogenic centers in target molecules with high enantiomeric purity.
• Peptidomimetics Research: Employed in the construction of morpholine-based peptidomimetics, which mimic peptides for enhanced metabolic stability.
• Medicinal Chemistry: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high stereochemical fidelity.

Basic Information

Product Name	(2R,6S)-4-tert-Butyl 2-Methyl 6-(Hydroxymethyl)Morpholine-2,4-Dicarboxylate
CAS No.	1951425-25-4
Molecular Formula	C13H23NO6
Molecular Weight	289.33 g/mol
Synonyms	(2R,6S)-4-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-6-(hydroxymethyl)morpholine; tert-Butyl (2R,6S)-2-(methoxycarbonyl)-6-(hydroxymethyl)morpholine-4-carboxylate; (2R,6S)-Morpholine-2,4-dicarboxylic acid, 6-(hydroxymethyl)-, 4-(1,1-dimethylethyl) 2-methyl ester; Boc-protected hydroxymethyl morpholine carboxylate; (2R,6S)-Boc-Morpholine-COOH(OMe)-CH2OH; Chiral Morpholine Ester Intermediate; CAS 1951425-25-4
EINECS	Contact for details

Quality Control

Our (2R,6S)-4-tert-Butyl 2-Methyl 6-(Hydroxymethyl)Morpholine-2,4-Dicarboxylate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.