Description

(2R,4S)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-Hydroxy-n-((S)-1-(4-(4-Methylthiazol-5-Yl)Phenyl)Ethyl)Pyrrolidine-2-Carboxamide Hydrochloride is a high-purity, non-natural amino acid derivative and a key chiral building block in advanced pharmaceutical synthesis. This compound is specifically engineered to serve as a critical intermediate in the development of targeted therapeutics, particularly proteolysis-targeting chimeras (PROTACs) and other novel modalities. It is essential for research institutions and pharmaceutical companies engaged in the discovery and process development of next-generation small molecule drugs, where precise stereochemistry and reliable quality are paramount for successful outcomes.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of complex drug candidates, especially in oncology and targeted protein degradation.
• PROTACs Development: Serves as a key component in the linker or warhead design of Proteolysis-Targeting Chimeras, enabling the creation of novel bifunctional molecules.
• Peptidomimetics Research: Used in the design and synthesis of peptide-like compounds with enhanced metabolic stability and bioavailability.
• Medicinal Chemistry: Provides a structurally complex scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-up: Supplied under GMP-like conditions for use in clinical trial material (CTM) manufacturing and commercial process development.
• Bioconjugation: The reactive amine and other functional groups make it suitable for conjugation chemistry in antibody-drug conjugate (ADC) or other bioconjugate research.

Basic Information

Product Name	(2R,4S)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-Hydroxy-n-((S)-1-(4-(4-Methylthiazol-5-Yl)Phenyl)Ethyl)Pyrrolidine-2-Carboxamide Hydrochloride
CAS No.	1948273-06-0
Molecular Formula	C25H37ClN4O4S
Molecular Weight	525.10 g/mol
Synonyms	PROTAC Linker 31; (2R,4S)-MZ 1 intermediate; (2R,4S)-VH032-C8-NH2 hydrochloride; (2R,4S)-VHL Ligand 2; (2R,4S)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride; (2R,4S)-VH032-C8-PEG3-NH2 HCl (core structure); VHL Ligand-Linker Conjugate 1 (stereospecific isomer); (2R,4S)-Epimer of VH032 derivative
EINECS	Contact for details

Quality Control

Our (2R,4S)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-Hydroxy-n-((S)-1-(4-(4-Methylthiazol-5-Yl)Phenyl)Ethyl)Pyrrolidine-2-Carboxamide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, chiral HPLC) are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled environment to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Assay (HPLC)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.