Description

(2S,4R)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-Hydroxy-n-((S)-1-(4-(4-Methylthiazol-5-Yl)Phenyl)Ethyl)Pyrrolidine-2-Carboxamide Hydrochloride CAS NO 1948273-03-7 is a high-purity, non-natural amino acid derivative and a key pharmaceutical intermediate. This compound is of significant commercial interest due to its role as a critical building block in the synthesis of complex therapeutic agents, particularly protease inhibitors. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel antiviral and anticancer drugs. The precise stereochemistry and functional groups make it an essential chiral synthon for advanced medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly those targeting viral proteases.
• Protease Inhibitor Development: Used in research and development of inhibitors for diseases such as HIV, Hepatitis C, and SARS-CoV-2.
• Antiviral Drug Synthesis: A key chiral building block for constructing complex molecular architectures in antiviral medications.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes.
• Peptidomimetic Compound Synthesis: Used to create stable, bioavailable mimics of natural peptide structures.
• Pre-clinical & Clinical Trial Material: Supplied as a high-quality intermediate for producing Active Pharmaceutical Ingredients (APIs) for non-clinical and clinical studies.
• Bioconjugation & Probe Development: Can be utilized for creating labeled compounds or probes for biochemical assays.

Basic Information

Product Name	(2S,4R)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-Hydroxy-n-((S)-1-(4-(4-Methylthiazol-5-Yl)Phenyl)Ethyl)Pyrrolidine-2-Carboxamide Hydrochloride
CAS No.	1948273-03-7
Molecular Formula	C25H37ClN4O4S
Molecular Weight	525.10 g/mol
Synonyms	PF-07321332 Intermediate; Nirmatrelvir Intermediate; SARS-CoV-2 3CL Protease Inhibitor Intermediate; (2S,4R)-1-[(2S)-2-Amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide hydrochloride; Paxlovid™ Key Intermediate; PF-07321332 HCl; 5-Thiazolecarboxamide derivative; Antiviral Intermediate 1948273-03-7
EINECS	Contact for details

Quality Control

Every batch of this pharmaceutical intermediate is produced under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality standards are designed to meet the rigorous requirements of GMP-grade manufacturing for pharmaceutical development and are supported by full traceability documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.