Description

tert-Butyl 8-Benzylhexahydro-1H-Pyrazino[1,2-A]Pyrazine-2(6H)-Carboxylate is a sophisticated heterocyclic building block and Boc-protected intermediate of significant value in advanced organic synthesis. This compound matters because it provides a protected nitrogen framework essential for constructing complex pharmaceutical molecules with precise stereochemistry and functional group compatibility. It is primarily needed by medicinal chemists and process development scientists in pharmaceutical R&D for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of complex drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to develop new therapeutic agents.
• Peptidomimetic Synthesis: Serves as a constrained scaffold to mimic peptide secondary structures, enhancing metabolic stability and bioavailability.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the commercial manufacturing of APIs under GMP guidelines.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A key starting material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical services.

Basic Information

Product Name	tert-Butyl 8-Benzylhexahydro-1H-Pyrazino[1,2-A]Pyrazine-2(6H)-Carboxylate
CAS No.	1936177-08-0
Molecular Formula	C19H29N3O2
Molecular Weight	331.46 g/mol
Synonyms	tert-Butyl 8-benzyl-1,2,3,4,6,7-hexahydropyrazino[1,2-a]pyrazine-2(6H)-carboxylate; 1,2,3,4,6,7-Hexahydro-8-(phenylmethyl)-, 2-(1,1-dimethylethyl) ester Pyrazino[1,2-a]pyrazine-2-carboxylic acid; 8-Benzyl-2-(tert-butoxycarbonyl)octahydropyrazino[1,2-a]pyrazine; Boc-8-benzyl-hexahydro-pyrazino[1,2-a]pyrazine; (6H)-tert-Butyl 8-benzylhexahydro-1H-pyrazino[1,2-a]pyrazine-2-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Benzylhexahydro-1H-Pyrazino[1,2-A]Pyrazine-2(6H)-Carboxylate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.