Description

6-Chloro-3-Iodo-1H-Pyrazolo[3,4-B]Pyrazine is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique halogenated pyrazolopyrazine scaffold, which serves as a versatile precursor for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel kinase inhibitors and other small-molecule therapeutics targeting various disease pathways.
• Agrochemical Research: Used in the synthesis of new active ingredients for crop protection products, leveraging its halogenated structure for bioactivity.
• Material Science Precursor: Serves as a building block for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic semiconductors.
• Chemical Biology Probe Development: Utilized to create tagged or modified chemical probes for studying biological processes and target engagement.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Library Synthesis for Drug Discovery: Employed in parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	6-Chloro-3-Iodo-1H-Pyrazolo[3,4-B]Pyrazine
CAS No.	1935196-58-9
Molecular Formula	C5H2ClIN4
Molecular Weight	279.45 g/mol
Synonyms	6-Chloro-3-iodo-1H-pyrazolo[3,4-b]pyrazine; 3-Iodo-6-chloro-1H-pyrazolo[3,4-b]pyrazine; 1H-Pyrazolo[3,4-b]pyrazine, 6-chloro-3-iodo-; 6-Chloro-3-iodopyrazolo[3,4-b]pyrazine; 1935196-58-9; 6-Chloro-3-iodo-1H-pyrazolo[3,4-b]pyrazine; 6-Chloro-3-iodo-1H-pyrazolo[3,4-b]pyrazine (CAS 1935196-58-9)
EINECS	Contact for details

Quality Control

Our 6-Chloro-3-Iodo-1H-Pyrazolo[3,4-B]Pyrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports research and development requiring high-purity, well-characterized building blocks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.