Description

1-Piperidinecarboxylic Acid, 3-Hydroxy-5-Methyl-, 1,1-Dimethylethyl Ester, (3R,5S)- is a high-purity, stereochemically defined chiral building block of significant importance in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecular architectures, particularly in the pharmaceutical sector where specific stereochemistry is critical for biological activity. This compound is essential for research chemists and process development scientists working in pharmaceutical R&D, agrochemicals, and fine chemical production who require reliable access to high-quality, enantiomerically pure intermediates.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting metabolic and central nervous system disorders.
• Agrochemical Research: Used in the development of enantiomerically pure pesticides and herbicides, where specific stereoisomers often exhibit enhanced efficacy and lower environmental impact.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of sophisticated chiral ligands and organocatalysts used in stereoselective transformations.
• Peptidomimetics & Bioactive Molecule Construction: The piperidine scaffold is incorporated into molecules designed to mimic peptide structures for drug discovery programs.
• Chemical Biology Probe Synthesis: Utilized in creating labeled or modified compounds for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Employed in route development and optimization for the commercial-scale manufacturing of chiral drugs.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 3-Hydroxy-5-Methyl-, 1,1-Dimethylethyl Ester, (3R,5S)-
CAS No.	1932597-68-6
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	(3R,5S)-tert-Butyl 3-hydroxy-5-methylpiperidine-1-carboxylate; (3R,5S)-3-Hydroxy-5-methyl-1-Boc-piperidine; (3R,5S)-1-Boc-3-hydroxy-5-methylpiperidine; (3R,5S)-N-Boc-3-hydroxy-5-methylpiperidine; (3R,5S)-3-Hydroxy-5-methylpiperidine-1-carboxylic acid tert-butyl ester; (3R,5S)-5-Methyl-3-hydroxypiperidine-1-carboxylic acid tert-butyl ester; (3R,5S)-rel-3-Hydroxy-5-methyl-1-Boc-piperidine; Boc-(3R,5S)-3-hydroxy-5-methylpiperidine
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, which is critical for downstream pharmaceutical applications. Quality is verified through advanced analytical techniques including Chiral HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.