Description

(3R,5S)-3-Amino-5-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, stereochemically defined piperidine derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a protected amino-hydroxy piperidine scaffold, enabling the efficient construction of complex molecules with precise stereochemical control. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for synthesizing novel active pharmaceutical ingredients (APIs), bioactive probes, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates, including protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where specific stereochemistry is crucial for biological activity.
• Chemical Biology & Medicinal Chemistry: Employed as a scaffold or building block for creating libraries of compounds in structure-activity relationship (SAR) studies and drug discovery programs.
• Catalyst & Ligand Development: Serves as a precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) engaged in synthetic methodology development and complex molecule synthesis.

Basic Information

Product Name	(3R,5S)-3-Amino-5-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1932513-59-1
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	tert-Butyl (3R,5S)-3-amino-5-hydroxypiperidine-1-carboxylate; (3R,5S)-3-Amino-5-hydroxypiperidine-1-carboxylic acid tert-butyl ester; 1-Boc-3-amino-5-hydroxypiperidine (stereoisomer); 1-(tert-Butoxycarbonyl)-3-amino-5-hydroxypiperidine; (3R,5S)-1-N-Boc-3-amino-5-hydroxypiperidine; (3R,5S)-3-Amino-5-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; (3R,5S)-3-Amino-5-hydroxy-piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (3R,5S)-3-Amino-5-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure high chemical and chiral purity, meeting the stringent requirements of research and development applications. We provide comprehensive analytical data including HPLC for purity, chiral HPLC for enantiomeric excess, and NMR for structural confirmation. Certificates of Analysis (COA) detailing lot-specific results are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.