Description

Nh-(Peg2-Acid)2 CAS NO 1919044-99-7 is a specialized bifunctional polyethylene glycol (PEG) derivative featuring two carboxylic acid termini, designed for advanced bioconjugation and linker applications. This compound is critical for creating stable, water-soluble crosslinks in the development of next-generation biopharmaceuticals and diagnostic reagents. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise and reliable heterobifunctional linkers.

Application

• Bioconjugation Linker: Serves as a key heterobifunctional reagent for covalently coupling biomolecules such as proteins, peptides, and antibodies to other entities like drugs, surfaces, or fluorescent dyes.
• ADC (Antibody-Drug Conjugate) Development: Used in the synthesis of linker-payload constructs for targeted cancer therapies, leveraging its PEG spacer to improve solubility and pharmacokinetics.
• Polymer Chemistry: Acts as a building block or macroinitiator for synthesizing functionalized, biocompatible polymers and hydrogels with tailored properties.
• Surface Functionalization: Enables the modification of nanoparticles, quantum dots, and biosensor surfaces with carboxyl groups for subsequent biomolecule immobilization.
• Diagnostic Reagent Synthesis: Integral in creating labeled probes and assay components for immunoassays and molecular diagnostics.
• Drug Delivery Systems: Incorporated into nanocarriers and micelles to enhance drug loading capacity and provide sites for targeted ligand attachment.

Basic Information

Product Name	Nh-(Peg2-Acid)2
CAS No.	1919044-99-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1,11-Bis(carboxymethyl)-3,6,9-trioxa-1,11-diazatridecane; PEG2-diacid NHS ester precursor; 2,2'-(Ethylenedioxy)bis(ethylamine) diacetic acid derivative; Bis-carboxymethyl-PEG2-amine; NH-(PEG)2-(COOH)2; Heterobifunctional PEG diacid; Amine-PEG2-diacid; PEG-based diacid linker
EINECS	Contact for details

Quality Control

Our Nh-(Peg2-Acid)2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions, preferably under an inert atmosphere such as nitrogen or argon, to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.