Description

3-Azabicyclo[4.1.0]heptane-2-carboxylic acid hydrochloride is a high-purity, bicyclic amino acid derivative hydrochloride salt, serving as a critical chiral building block in advanced organic synthesis. Its constrained, fused ring system provides a unique three-dimensional scaffold essential for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily utilized by pharmaceutical R&D and process chemistry teams in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disease targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, especially those targeting neurological receptors and enzymes.
• Medicinal Chemistry Research: Used to introduce a rigid, bicyclic proline-like motif into compound libraries for structure-activity relationship (SAR) studies.
• Peptidomimetics Development: Serves as a constrained amino acid analog for designing novel peptide mimics with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a building block in catalytic asymmetric reactions to construct stereochemically complex molecular architectures.
• Chemical Biology Probes: Utilized in the development of tool compounds and probes for investigating biological pathways and protein function.
• Process Chemistry & Scale-up: Supports route scouting and optimization for the commercial-scale manufacturing of pharmaceutical compounds.

Basic Information

Item	Details
Product Name	3-Azabicyclo[4.1.0]heptane-2-carboxylic acid hydrochloride
CAS No.	1888587-45-8
Molecular Formula	C7H12ClNO2
Molecular Weight	177.63 g/mol
Synonyms	1-Azabicyclo[4.1.0]heptane-2-carboxylic acid hydrochloride (alternative numbering); (1R,2S,6R)-3-Azabicyclo[4.1.0]heptane-2-carboxylic acid hydrochloride (stereoisomer); 2-Carboxy-3-azabicyclo[4.1.0]heptane hydrochloride; Bicycloproline hydrochloride; 3-Azabicyclo[4.1.0]heptane-2-carboxylic acid HCl; 1888587-45-8; Constrained proline derivative hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Azabicyclo[4.1.0]heptane-2-carboxylic acid hydrochloride is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccated environment after opening to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.