Description

(S)-1,5-Dimethylpiperazin-2-One Hydrochloride CAS NO 1887197-43-4 is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. This compound is valued for its role in the synthesis of complex molecules, particularly in medicinal chemistry and drug discovery. It is primarily needed by research institutions, pharmaceutical development companies, and fine chemical manufacturers focused on creating novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce specific stereochemistry and functional groups into candidate drug molecules.
• Asymmetric Synthesis: Serves as a chiral auxiliary or precursor in catalytic and stoichiometric asymmetric synthesis to control stereoselectivity.
• Peptidomimetics Development: Incorporated into the design of peptidomimetic compounds, where the piperazinone scaffold mimics peptide bonds and provides conformational constraint.
• Chemical Biology Probes: Utilized in the creation of specialized chemical probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP or non-GMP conditions.

Basic Information

Product Name	(S)-1,5-Dimethylpiperazin-2-One Hydrochloride
CAS No.	1887197-43-4
Molecular Formula	C7H15ClN2O
Molecular Weight	178.66 g/mol
Synonyms	(S)-1,5-Dimethyl-2-piperazinone hydrochloride; (3S)-1,5-Dimethyl-3,4,5,6-tetrahydropyrazin-2(1H)-one hydrochloride; (S)-1,5-Dimethylpiperazin-2-one HCl; (S)-1,5-Dimethyl-2-oxopiperazine hydrochloride; (S)-1,5-Dimethyl-2-ketopiperazine hydrochloride; (S)-1,5-Dimethyl-2-piperazinone monohydrochloride; (S)-1,5-Dimethylpiperazin-2-one monohydrochloride
EINECS	Contact for details

Quality Control

Our (S)-1,5-Dimethylpiperazin-2-One Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing identity, purity, and impurity profiles. Our quality systems support development from research-grade to cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.