Description

6-[4-(Trifluoromethyl)Phenyl]Pyrazine-2-Carboxylic Acid is a high-value, multifunctional heterocyclic building block characterized by its pyrazine core and trifluoromethylphenyl substituent. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical candidates and agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is needed by research and development chemists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules with tailored properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and fungicides, leveraging the bioactivity-enhancing trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or fluorinated polymers.
• Chemical Biology Probes: Useful for designing molecular probes and tags to study biological processes due to its derivatizable carboxylic acid and aromatic systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific fluorinated heterocycle.

Basic Information

Product Name	6-[4-(Trifluoromethyl)Phenyl]Pyrazine-2-Carboxylic Acid
CAS No.	1864014-28-7
Molecular Formula	C12H7F3N2O2
Molecular Weight	268.19 g/mol
Synonyms	6-[4-(Trifluoromethyl)phenyl]pyrazine-2-carboxylic acid; 2-Pyrazinecarboxylic acid, 6-[4-(trifluoromethyl)phenyl]-; 6-(4-Trifluoromethylphenyl)pyrazine-2-carboxylic acid; 6-(4-(Trifluoromethyl)phenyl)pyrazine-2-carboxylic acid; 1864014-28-7; 6-(4-Trifluoromethyl-phenyl)-pyrazine-2-carboxylic acid; 6-(α,α,α-Trifluoro-p-tolyl)pyrazine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 6-[4-(Trifluoromethyl)Phenyl]Pyrazine-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements, supporting compliance in GMP and ISO environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.