Description

1-Benzyl-4-Bicyclo[1.1.1]Pent-1-Yl-Piperazine is a high-value, structurally complex piperazine derivative featuring a rigid bicyclo[1.1.1]pentane (BCP) bridgehead substituent. This compound is of significant interest in modern medicinal chemistry and pharmaceutical research due to its unique three-dimensional geometry, which is highly effective for improving the physicochemical and pharmacokinetic properties of drug candidates. It serves as a critical advanced pharmaceutical intermediate for researchers and developers in the life sciences sector seeking to create novel therapeutics with enhanced metabolic stability and membrane permeability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to incorporate the favorable BCP bioisostere, replacing traditional aromatic or aliphatic rings.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component in the design of bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying protein function and biological pathways.
• Agrochemical Research: Potential intermediate for developing new generation crop protection agents with novel modes of action.
• Material Science: Investigated as a monomer or cross-linking agent for creating polymers with unique mechanical properties.

Basic Information

Product Name	1-Benzyl-4-Bicyclo[1.1.1]Pent-1-Yl-Piperazine
CAS No.	1862201-59-9
Molecular Formula	C16H22N2
Molecular Weight	242.36 g/mol
Synonyms	4-(Bicyclo[1.1.1]pentan-1-yl)-1-benzylpiperazine; 1-Benzyl-4-(bicyclo[1.1.1]pent-1-yl)piperazine; BCP-Piperazine Derivative; 1-BCP-Piperazine; 1-Benzyl-4-(1-bicyclo[1.1.1]pentanyl)piperazine; Benzyl-BCP-piperazine; [1,1'-Biphenyl]-4-amine, 3',5'-dichloro- (alternative structural naming context)
EINECS	Contact for details

Quality Control

Our production of 1-Benzyl-4-Bicyclo[1.1.1]Pent-1-Yl-Piperazine adheres to stringent internal quality standards, ensuring batch-to-batch consistency suitable for research and development. Identity and purity are confirmed via advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support development under cGMP guidelines for projects requiring regulatory filing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.