Description

[(2S)-4-Benzylpiperazin-2-Yl]Methanol Dihydrochloride is a high-purity chiral piperazine derivative, a crucial building block in modern pharmaceutical research and development. This compound serves as a versatile synthetic intermediate, enabling the creation of complex molecules with specific stereochemistry. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of active pharmaceutical ingredients (APIs) and novel therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, particularly those targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug discovery programs.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and route development for API manufacturing.
• Ligand Synthesis: Employed in the preparation of chiral ligands for asymmetric catalysis.
• Chemical Biology Probes: Utilized to develop tool compounds for studying biological pathways and target validation.

Basic Information

Product Name	[(2S)-4-Benzylpiperazin-2-Yl]Methanol Dihydrochloride
CAS No.	1860012-50-5
Molecular Formula	C12H20Cl2N2O
Molecular Weight	279.21 g/mol
Synonyms	(S)-4-Benzyl-2-(hydroxymethyl)piperazine Dihydrochloride; (2S)-4-Benzyl-2-piperazinemethanol Dihydrochloride; (S)-1-Benzyl-3-(hydroxymethyl)piperazine Dihydrochloride; (2S)-1-Benzyl-3-(hydroxymethyl)piperazine Dihydrochloride; (S)-4-Benzyl-2-(hydroxymethyl)piperazine Hydrochloride (1:2); (S)-2-(Hydroxymethyl)-4-benzylpiperazine Dihydrochloride; 1-Benzyl-(2S)-piperazin-2-yl-methanol Dihydrochloride
EINECS	Contact for details

Quality Control

Our [(2S)-4-Benzylpiperazin-2-Yl]Methanol Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and residual solvent levels is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.