Description

Boc-Aminooxy-Peg3-Acid is a heterobifunctional polyethylene glycol (PEG) linker featuring a tert-butoxycarbonyl (Boc)-protected aminooxy group and a carboxylic acid terminus. This compound is specifically engineered for the controlled conjugation of biomolecules, offering a hydrophilic spacer that enhances solubility and reduces immunogenicity. It is a critical reagent for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, enabling the precise construction of antibody-drug conjugates (ADCs), peptide therapeutics, and functionalized surfaces.

Application

• Bioconjugation and ADC Development: Used as a key linker to connect cytotoxic drugs to monoclonal antibodies via oxime bond formation, creating stable and targeted therapeutics.
• Peptide and Protein Modification: Facilitates site-specific labeling or PEGylation of peptides and proteins through reaction with carbonyl groups (aldehydes, ketones).
• Surface Functionalization: Employed to modify nanoparticles, biosensors, and chromatography matrices with bioactive ligands for diagnostic and separation applications.
• Crosslinking Agent: Acts as a heterobifunctional crosslinker for coupling molecules containing amine and carbonyl functionalities in a controlled, stepwise manner.
• Polymer Chemistry: Serves as a functional monomer or initiator for synthesizing advanced, biocompatible polymeric materials with tailored properties.
• Chemical Biology Probes: Integral for synthesizing activity-based probes and affinity tags to study protein function and interactions in complex biological systems.

Basic Information

Product Name	Boc-Aminooxy-Peg3-Acid
CAS No.	1835759-82-4
Molecular Formula	C16H31NO8
Molecular Weight	365.42 g/mol
Synonyms	1-Boc-aminooxy-3,6,9-trioxa-12-azatetradecan-14-oic acid; 15-[(1,1-Dimethylethoxycarbonyl)amino]-4,7,10-trioxa-13-azapentadecanoic acid; Boc-NH-O-PEG3-COOH; t-Butyl (14-carboxy-3,6,9-trioxa-12-azatetradecyl)carbamate; Amino-PEG3-acid, Boc-protected; Boc-Aminooxy-PEG3-propionic acid; tert-Butyl (3,6,9-trioxa-12-azatetradec-13-yl)carbamate 14-carboxylic acid
EINECS	Contact for details

Quality Control

Our Boc-Aminooxy-Peg3-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.