Description

tert-Butyl (3-Fluorobicyclo[1.1.1]pentan-1-yl)carbamate (Wx120747) is a high-purity, advanced pharmaceutical intermediate featuring a unique, rigid bicyclo[1.1.1]pentane (BCP) scaffold. This compound is specifically engineered to serve as a key building block in modern drug discovery, offering significant advantages for improving the pharmacokinetic and physicochemical properties of bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas such as medicinal chemistry, agrochemicals, and materials science.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Medicinal Chemistry & Drug Discovery: Used as a bioisostere for para-substituted benzene rings or tert-butyl groups to enhance metabolic stability, solubility, and reduce lipophilicity in lead optimization.
• Agrochemical Research: Employed in the development of novel pesticides and herbicides, where the BCP core can contribute to improved environmental and degradation profiles.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Serves as a versatile linker or component in bifunctional molecules for targeted protein degradation.
• Materials Science: Investigated for the synthesis of advanced polymers and functional materials with unique steric and electronic properties.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring high-fidelity, structurally complex intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl (3-Fluorobicyclo[1.1.1]pentan-1-yl)carbamate (Wx120747)
CAS No.	1826900-85-9
Molecular Formula	C10H16FNO2
Molecular Weight	201.24 g/mol
Synonyms	1-Boc-3-fluorobicyclo[1.1.1]pentane-1-amine; tert-Butyl N-(3-fluorobicyclo[1.1.1]pentan-1-yl)carbamate; 3-Fluoro-1-Boc-aminobicyclo[1.1.1]pentane; 1-Amino-3-fluorobicyclo[1.1.1]pentane-1-carboxylic acid tert-butyl ester; Boc-3-F-BCP-NH2; Wx120747; Bicyclo[1.1.1]pentane-1-carboxamide, N-(1,1-dimethylethyl)-3-fluoro-; 3-Fluoro-BCP-Boc-amine
EINECS	Contact for details

Quality Control

Our tert-Butyl (3-Fluorobicyclo[1.1.1]pentan-1-yl)carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Production can be aligned with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to maintain product integrity and prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.