Description

tert-Butyl 3-((Piperazin-1-yl)methyl)azetidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold combining azetidine and piperazine moieties. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules with potential therapeutic applications. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new drug candidates, particularly in areas requiring sophisticated nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new drug candidates.
• Proteolysis Targeting Chimera (PROTAC) Development: The piperazine linker and azetidine group make it a valuable component for constructing bifunctional molecules like PROTACs.
• Kinase Inhibitor Synthesis: Employed in the creation of potential kinase inhibitors due to its ability to modulate solubility and binding affinity.
• Chemical Biology Probes: Acts as a precursor for developing molecular probes to study biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl 3-((Piperazin-1-yl)methyl)azetidine-1-carboxylate
CAS No.	1823977-00-9
Molecular Formula	C13H25N3O2
Molecular Weight	255.36 g/mol
Synonyms	1-Boc-3-(piperazin-1-ylmethyl)azetidine; tert-Butyl 3-(piperazin-1-ylmethyl)azetidine-1-carboxylate; 3-(Piperazin-1-ylmethyl)azetidine-1-carboxylic acid tert-butyl ester; 1-(1,1-Dimethylethyl) 3-[(1-piperazinyl)methyl]-1-azetidinecarboxylate; Azetidine-1-carboxylic acid, 3-[(1-piperazinyl)methyl]-, 1,1-dimethylethyl ester; 1823977-00-9; BOC-3-Piperazin-1-ylmethyl-azetidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-((Piperazin-1-yl)methyl)azetidine-1-carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development under various quality regimes, from research-grade to cGMP standards for advanced clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed under an inert atmosphere if necessary to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.