Description

tert-Butyl 2-Iodo-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate (Wx141846) is a high-purity, advanced pharmaceutical intermediate featuring a halogenated, fused heterocyclic structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Organoiodine Compound Synthesis: The iodine substituent makes it a valuable reagent for cross-coupling reactions, such as Suzuki or Sonogashira couplings, to construct complex molecular architectures.
• Proteolysis Targeting Chimera (PROTAC) Development: Its structure is suitable for incorporation into bifunctional molecules designed for targeted protein degradation.
• Chemical Biology Probes: Can be used to develop molecular probes for studying biological pathways and target engagement.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical and biotech clients with custom synthesis projects.

Basic Information

Item	Details
Product Name	tert-Butyl 2-Iodo-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate (Wx141846)
CAS No.	1823835-34-2
Molecular Formula	C11H14IN3O2
Molecular Weight	347.15 g/mol
Synonyms	tert-Butyl 2-iodo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-5-carboxylate; 5-(tert-Butoxycarbonyl)-2-iodo-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine; WX-141846; Wx141846; 2-Iodo-5-Boc-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine; Boc-2-Iodo-DHPP; 1823835-34-2
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Iodo-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Keep the container sealed under an inert atmosphere if prolonged storage is required to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.