Description

2-Bromo-6,7-Dihydro-5H-Pyrrolo[3,4-B]Pyrazine Hydrochloride is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a versatile and valuable building block for the synthesis of complex heterocyclic molecules, particularly in medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including kinase inhibitors and other small-molecule drugs targeting various disease pathways.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs), especially for oncology and CNS disorders.
• Medicinal Chemistry Research: Used as a core scaffold or building block for constructing libraries of compounds in high-throughput screening and structure-activity relationship (SAR) studies.
• Kinase Inhibitor Synthesis: Integral to the synthesis of potent and selective kinase inhibitors, a major class of targeted cancer therapies.
• Chemical Biology Probes: Employed in the creation of molecular probes to study biological pathways and protein functions.
• Process Chemistry & Scale-up: Serves as a critical intermediate during the optimization and commercial scale-up of drug candidate synthesis.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical industry.

Basic Information

Product Name	2-Bromo-6,7-Dihydro-5H-Pyrrolo[3,4-B]Pyrazine Hydrochloride
CAS No.	1823379-27-6
Molecular Formula	C7H8BrClN3
Molecular Weight	249.52 g/mol
Synonyms	2-Bromo-5,6,7,8-tetrahydropyrrolo[3,4-b]pyrazine hydrochloride; 2-Bromo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine HCl; 2-Bromo-5,6,7,8-tetrahydro-pyrrolo[3,4-b]pyrazine hydrochloride; Pyrrolo[3,4-b]pyrazine, 2-bromo-6,7-dihydro-5H-, hydrochloride (1:1); 1823379-27-6; 2-Bromo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine monohydrochloride
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-6,7-Dihydro-5H-Pyrrolo[3,4-B]Pyrazine Hydrochloride is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our commitment to GMP-grade standards for advanced intermediates ensures the material is suitable for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to exclude moisture and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.