Description

5-Chloro-3-Iodopyrazin-2-Amine is a high-purity halogenated pyrazine derivative, serving as a critical building block in advanced organic synthesis. Its unique bifunctional halogen pattern makes it a versatile intermediate for constructing complex heterocyclic systems and active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries seeking to introduce specific halogenated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and pesticides, leveraging its halogenated pyrazine core.
• Material Science Research: Serves as a monomer or functional unit in the creation of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology: Employed as a probe or linker in bioconjugation chemistry and the development of chemical tools for biological studies.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for Suzuki, Sonogashira, and Buchwald-Hartwig cross-coupling reactions.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries in high-throughput screening and medicinal chemistry programs.

Basic Information

Product Name	5-Chloro-3-Iodopyrazin-2-Amine
CAS No.	1823290-98-7
Molecular Formula	C4H3ClIN3
Molecular Weight	255.44 g/mol
Synonyms	2-Amino-5-chloro-3-iodopyrazine; 3-Iodo-5-chloropyrazin-2-amine; 5-Chloro-3-iodo-2-pyrazinamine; 5-Chloro-3-iodopyrazin-2-ylamine; 1823290-98-7; 5-Chloro-3-iodo-2-aminopyrazine; 2-Pyrazinamine, 5-chloro-3-iodo-
EINECS	Contact for details

Quality Control

Our 5-Chloro-3-Iodopyrazin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality protocols to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.