Description

tert-Butyl 6,7-Dihydro-3-Iodopyrazolo[1,5-A]Pyrazine-5(4H)-Carboxylate is a high-value, iodinated heterocyclic building block of significant interest in modern synthetic chemistry. This compound serves as a critical intermediate for the construction of complex molecular architectures, particularly in pharmaceutical research and development. It is primarily sought after by medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially within kinase inhibitor and other targeted therapeutic programs. The tert-butyloxycarbonyl (Boc) protecting group offers excellent synthetic versatility for further selective functionalization.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around the pyrazolopyrazine core.
• Process Chemistry Development: Serves as a scalable building block for the development of robust and cost-effective synthetic routes to target molecules under Good Manufacturing Practice (GMP) guidelines.
• Agrochemical Research: Potential intermediate in the discovery of new active ingredients for crop protection products.
• Chemical Biology Probes: Can be utilized to create tagged or modified molecules for studying biological pathways and target engagement.
• Academic & Contract Research: Employed in universities and CROs for methodological development and the synthesis of complex heterocycles.

Basic Information

Product Name	tert-Butyl 6,7-Dihydro-3-Iodopyrazolo[1,5-A]Pyrazine-5(4H)-Carboxylate
CAS No.	1823229-68-0
Molecular Formula	C11H14IN3O2
Molecular Weight	347.15 g/mol
Synonyms	tert-Butyl 3-iodo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-5-carboxylate; 5-Boc-3-iodo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine; 3-Iodo-5-((tert-butoxycarbonyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine; Boc-3-Iodo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine; tert-Butyl 3-iodo-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxylate; 1823229-68-0; SCHEMBL24245419
EINECS	Contact for details

Quality Control

Our tert-Butyl 6,7-Dihydro-3-Iodopyrazolo[1,5-A]Pyrazine-5(4H)-Carboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.