Description

7-(tert-Butoxycarbonyl)-5,6,7,8-Tetrahydroimidazo[1,5-A]Pyrazine-5-Carboxylic Acid (Wx141780) is a high-purity, advanced pharmaceutical intermediate featuring a protected carboxylic acid and a Boc-protected tetrahydroimidazopyrazine scaffold. This compound is of critical importance for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of targeted therapies. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the discovery and production of novel small-molecule drugs, especially within oncology and central nervous system (CNS) therapeutic areas.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block for constructing complex drug molecules, particularly those containing the imidazopyrazine pharmacophore.
• Pharmaceutical Research & Development: Used in medicinal chemistry for lead optimization and the creation of novel chemical entities in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Its structure makes it a potential component in the linker or ligand portions of bifunctional PROTAC molecules.
• Kinase Inhibitor Precursor: Acts as a precursor in the synthesis of selective kinase inhibitors, a major class of oncology therapeutics.
• Peptidomimetic Chemistry: Utilized in the design and synthesis of peptidomimetics to enhance metabolic stability and bioavailability of peptide-based drugs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	7-(tert-Butoxycarbonyl)-5,6,7,8-Tetrahydroimidazo[1,5-A]Pyrazine-5-Carboxylic Acid (Wx141780)
CAS No.	1822512-31-1
Molecular Formula	C12H17N3O4
Molecular Weight	267.28 g/mol
Synonyms	5,6,7,8-Tetrahydroimidazo[1,5-a]pyrazine-5-carboxylic acid, 7-[(1,1-dimethylethoxy)carbonyl]-; Boc-THIP-5-COOH; 7-Boc-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-5-carboxylic acid; WX-141780; tert-Butyl 5-carboxy-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-7-carboxylate; Imidazo[1,5-a]pyrazine-5-carboxylic acid derivative; Pharmaceutical Intermediate Wx141780
EINECS	Contact for details

Quality Control

Our 7-(tert-Butoxycarbonyl)-5,6,7,8-Tetrahydroimidazo[1,5-A]Pyrazine-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity suitable for pharmaceutical R&D and cGMP applications. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided with every shipment to ensure full traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.