Description

(3R,4S)-tert-Butyl 3-Amino-4-Methylpiperidine-1-Carboxylate is a high-purity, stereochemically defined piperidine derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, protected amine scaffold essential for constructing complex molecules with precise three-dimensional architecture. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for applications in medicinal chemistry, particularly in the development of active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potent drug candidates, especially for central nervous system (CNS) and antiviral therapies.
• Asymmetric Catalysis Ligand Precursor: Used to construct sophisticated chiral ligands for metal-catalyzed asymmetric transformations.
• Peptidomimetics & Constrained Analog Design: Incorporates conformational rigidity into peptide backbones to enhance metabolic stability and receptor selectivity.
• Agrochemical Research: Serves as a building block for developing novel, stereospecific pesticides and herbicides.
• Academic & Process Chemistry: Employed in methodological research and scale-up studies for novel synthetic routes.
• Custom Synthesis Projects: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client pipelines.

Basic Information

Product Name	(3R,4S)-tert-Butyl 3-Amino-4-Methylpiperidine-1-Carboxylate
CAS No.	1821822-30-3
Molecular Formula	C11H22N2O2
Molecular Weight	214.31 g/mol
Synonyms	1-Boc-3-amino-4-methylpiperidine (stereospecific); tert-Butyl (3R,4S)-3-amino-4-methylpiperidine-1-carboxylate; (3R,4S)-1-N-Boc-3-amino-4-methylpiperidine; 4-Methyl-3-aminopiperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-amino-4-methylpiperidine; BOC-3-Amino-4-methylpiperidine (R,S); 1821822-30-3; UNII-Contact for details
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) are available upon request, detailing specifications for assay, enantiomeric excess, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.