Description

Benzyl (3R,4R)-4-Amino-3-Fluoropiperidine-1-Carboxylate is a high-purity, chiral fluorinated piperidine derivative that serves as a critical advanced pharmaceutical intermediate (API intermediate). This compound is valued for its role in constructing complex molecular architectures, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting the central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D departments, contract research and manufacturing organizations (CROs/CMOs), and fine chemical producers engaged in the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug candidates, particularly those requiring a fluorinated piperidine scaffold.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for new chemical entities (NCEs), especially in neurology and psychiatry.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Serves as a chiral synthon for constructing enantiomerically pure compounds in fine chemical and custom synthesis.
• Pre-clinical and Clinical Trial Material Production: Supplied under controlled conditions for the manufacture of batches intended for regulatory studies.
• Process Chemistry Scale-up: Used in the development and optimization of scalable synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	Benzyl (3R,4R)-4-Amino-3-Fluoropiperidine-1-Carboxylate
CAS No.	1821811-10-2
Molecular Formula	C13H17FN2O2
Molecular Weight	252.29 g/mol
Synonyms	1-Carbobenzyloxy-3-fluoro-4-aminopiperidine; (3R,4R)-1-(Benzyloxycarbonyl)-3-fluoro-4-aminopiperidine; 3-Fluoro-4-aminopiperidine-1-carboxylic acid benzyl ester; Benzyl N-[(3R,4R)-3-fluoro-4-aminopiperidin-1-yl]formate; 1-CBZ-3-Fluoro-4-Aminopiperidine; (3R,4R)-4-Amino-3-fluoropiperidine-1-carboxylic acid benzyl ester; 4-Amino-3-fluoropiperidine-1-carboxylate benzyl ester
EINECS	Contact for details

Quality Control

Our Benzyl (3R,4R)-4-Amino-3-Fluoropiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and chemical purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (enantiomeric excess)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.