Description

(1R,3R,5S)-3-(Pyridin-2-Yloxy)-8-Azabicyclo[3.2.1]Octane Dihydrochloride is a high-purity, chiral bicyclic amine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block or intermediate for synthesizing novel active pharmaceutical ingredients (APIs), particularly in the central nervous system (CNS) and therapeutic areas targeting specific receptor systems. Its precise stereochemistry and functionalization make it valuable for medicinal chemists and process development scientists working on innovative drug candidates, requiring reliable supply and stringent quality control.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Used in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry & Scale-Up: Serves as a starting material or advanced intermediate for process route development and GMP manufacturing.
• Neurological & CNS Drug Development: Potential intermediate for therapeutics targeting neurological disorders, given its structural similarity to tropane alkaloids.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring high-purity, complex chiral amines.

Basic Information

Product Name	(1R,3R,5S)-3-(Pyridin-2-Yloxy)-8-Azabicyclo[3.2.1]Octane Dihydrochloride
CAS No.	1820664-70-7
Molecular Formula	C12H17N2O•2HCl
Molecular Weight	277.20 g/mol (Free base: 205.28 g/mol)
Synonyms	8-Azabicyclo[3.2.1]octane, 3-(2-pyridinyloxy)-, (1R,3R,5S)-, dihydrochloride; (1R,3R,5S)-3-(Pyridin-2-yloxy)-8-azabicyclo[3.2.1]octane dihydrochloride; (1R,3R,5S)-Tropane-3-yl pyridin-2-yl ether dihydrochloride; endo-3-(Pyridin-2-yloxy)-8-azabicyclo[3.2.1]octane dihydrochloride; (1R,3R,5S)-3-[(Pyridin-2-yl)oxy]-8-azabicyclo[3.2.1]octane dihydrochloride
EINECS	Contact for details

Quality Control

Our (1R,3R,5S)-3-(Pyridin-2-Yloxy)-8-Azabicyclo[3.2.1]Octane Dihydrochloride is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support development with custom specifications and are equipped to scale production under cGMP guidelines as projects advance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccants or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.