Description

(R)-4-Methyl-3-(Hydroxymethyl)Morpholine Hydrochloride is a high-purity chiral building block and intermediate of significant interest in advanced organic synthesis. Its value lies in its stereochemically defined morpholine core, which is a privileged scaffold for modulating the physicochemical and biological properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly where specific enantiomeric purity is critical for efficacy and safety.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new drug candidates, especially in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and insecticides to enhance activity and reduce environmental impact.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Academic & Institutional Research: Used in university and institutional labs for methodological development in organic chemistry and medicinal chemistry projects.

Basic Information

Product Name	(R)-4-Methyl-3-(Hydroxymethyl)Morpholine Hydrochloride
CAS No.	1820569-49-0
Molecular Formula	C6H14ClNO2
Molecular Weight	167.63 g/mol
Synonyms	(3R)-4-Methyl-3-(hydroxymethyl)morpholine hydrochloride; (R)-4-Methylmorpholin-3-ylmethanol hydrochloride; (R)-3-(Hydroxymethyl)-4-methylmorpholine HCl; 4-Methyl-3-(hydroxymethyl)morpholine hydrochloride, (R)-; Morpholine, 4-methyl-3-(hydroxymethyl)-, hydrochloride, (3R)-; (R)-HMM-HCl
EINECS	Contact for details

Quality Control

Our (R)-4-Methyl-3-(Hydroxymethyl)Morpholine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure it meets the high-purity standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain product integrity. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.