Description

1β-Acetoxypolygodial is a specialized sesquiterpene derivative, a semi-synthetic analog of the natural product polygodial. This compound matters for its role as a key synthetic intermediate and a promising scaffold for developing novel bioactive molecules. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for applications in drug discovery and advanced material synthesis.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel therapeutic agents, particularly those targeting inflammation and microbial infections.
• Medicinal Chemistry Research: Used as a reference standard and a core structure for structure-activity relationship (SAR) studies in drug discovery programs.
• Agrochemical Development: Investigated as a precursor for creating new crop protection agents with potential insecticidal or fungicidal activity.
• Natural Product Analog Synthesis: Enables the chemical modification and diversification of the polygodial backbone to explore new chemical spaces and bioactivities.
• Biochemical Research: Employed in studies to understand the mechanism of action of drimane-type sesquiterpenoids and their interaction with biological targets.
• Fine Chemical Synthesis: Utilized in multi-step organic syntheses to introduce complex chiral and functional elements into target molecules.

Basic Information

Product Name	1β-Acetoxypolygodial
CAS No.	1818425-44-3
Molecular Formula	C17H24O5
Molecular Weight	308.37 g/mol
Synonyms	1β-Acetoxypolygodial; Polygodial 1β-acetate; (1R,4aS,8aS)-1-[(Acetyloxy)methyl]-5,5,8a-trimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene-4a-carbaldehyde; Driman-8,11-dial 1β-acetate; 1β-Acetoxy-9-deoxy-9-oxo-α-santonin (related structural class)
EINECS	Contact for details

Quality Control

Our 1β-Acetoxypolygodial is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated place separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.