Description

m-Peg12-Aldehyde is a monodisperse, functionalized polyethylene glycol derivative featuring a reactive aldehyde group at one terminus. This compound is a crucial building block in bioconjugation and pharmaceutical development, enabling the precise, site-specific modification of biomolecules such as proteins, peptides, and antibodies. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, advanced drug delivery systems, and diagnostic reagent development.

Application

• Bioconjugation Reagent: For the site-specific PEGylation of therapeutic proteins and peptides to enhance pharmacokinetic properties.
• Linker Chemistry: Acts as a heterobifunctional crosslinker for coupling amines (via reductive amination) to other functional groups in complex molecule synthesis.
• Drug Delivery Systems: Used in the formulation of antibody-drug conjugates (ADCs) and nanoparticle-based delivery platforms.
• Surface Functionalization: For modifying sensor surfaces, microarrays, and biomaterials to introduce aldehyde groups for further immobilization.
• Hydrogel Formation: Serves as a crosslinking agent in the creation of biocompatible hydrogels for tissue engineering and controlled release.
• Diagnostic Assays: Employed in the development of enzyme-linked immunosorbent assays (ELISA) and other diagnostic tools.

Basic Information

Product Name	m-Peg12-Aldehyde
CAS No.	1818294-51-7
Molecular Formula	C27H54O13
Molecular Weight	586.71 g/mol
Synonyms	mPEG12-CHO; Methoxy-PEG12-aldehyde; α-Methoxy-ω-aldehyde-poly(ethylene glycol) (12 units); 2,5,8,11,14,17,20,23,26,29,32,35-Dodecaoxaheptatetracontan-37-al; Monomethoxy PEG Aldehyde (n=12); O-(2-Aminoethyl)-O'-(2-carboxyethyl)undecaethylene glycol; Aldehyde-PEG-OMe (MW 600)
EINECS	Contact for details

Quality Control

Our m-Peg12-Aldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Aldehyde Content)	≥ 90%
Water Content (KF)	≤ 1.0%
Molecular Weight (GPC)	580 - 600 g/mol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.