Description

(R)-tert-Butyl 4-Benzyl-3-(Hydroxymethyl)Piperazine-1-Carboxylate is a high-purity, chiral piperazine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the development of active pharmaceutical ingredients (APIs), enabling the creation of enantiomerically pure therapeutics. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers focused on producing novel drugs, particularly in areas like oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Utilized in the construction of enantiomerically pure molecules for medicinal chemistry and process development.
• Protease Inhibitor Research: Serves as a core structural component in the development of protease inhibitors for antiviral and anticancer therapies.
• Ligand and Catalyst Development: Used in the preparation of chiral ligands and organocatalysts for stereoselective transformations.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high chiral purity.

Basic Information

Product Name	(R)-tert-Butyl 4-Benzyl-3-(Hydroxymethyl)Piperazine-1-Carboxylate
CAS No.	1817678-56-0
Molecular Formula	C17H26N2O3
Molecular Weight	306.40 g/mol
Synonyms	1-Boc-4-benzyl-3-(hydroxymethyl)-(R)-piperazine; (R)-1-(tert-Butoxycarbonyl)-4-benzyl-3-(hydroxymethyl)piperazine; (R)-tert-Butyl 4-benzyl-3-(hydroxymethyl)-1-piperazinecarboxylate; (R)-N-Boc-4-benzyl-3-piperazinemethanol; (3R)-1-(tert-Butoxycarbonyl)-4-benzyl-3-(hydroxymethyl)piperazine; (R)-1-Boc-4-benzyl-3-hydroxymethylpiperazine; BOC-4-Bzl-3-CH2OH-(R)-Piperazine
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 4-Benzyl-3-(Hydroxymethyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure compliance with stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.