Description

Alfacalcidol is a synthetic analog of vitamin D, specifically a prohormone of calcitriol (1,25-dihydroxyvitamin D3). This compound is critical for regulating calcium and phosphate metabolism in the body, making it a vital active pharmaceutical ingredient (API). It is primarily required by the pharmaceutical industry for the formulation of prescription medications used to treat conditions such as hypocalcemia, secondary hyperparathyroidism, and metabolic bone diseases associated with chronic kidney disease.

Application

• Pharmaceutical API: Core active ingredient in prescription drugs for treating renal osteodystrophy and hypoparathyroidism.
• Metabolic Bone Disease Treatment: Used in medications for osteoporosis and other disorders of bone mineralization.
• Vitamin D Therapy: Formulated in treatments for vitamin D deficiency where rapid correction is needed.
• Hormone Replacement Preparations: Incorporated into specialized hormonal therapies.
• Clinical Research: Serves as a reference standard and key material in endocrinology and nephrology research.
• Veterinary Pharmaceuticals: Used in formulations for treating calcium and bone disorders in animals.

Basic Information

Product Name	Alfacalcidol
CAS No.	1809782-28-2
Molecular Formula	C₂₇H₄₄O₂
Molecular Weight	400.64 g/mol
Synonyms	1α-Hydroxycholecalciferol; 1α-Hydroxyvitamin D3; 1α-OH-D3; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β-diol; Alfacalcidolum; Alfacalcidol (USP); Alfacalcidol (EP)
EINECS	Contact for details

Quality Control

Our Alfacalcidol is manufactured under strict quality management systems. It is tested to meet or exceed relevant pharmacopeial standards, including USP and EP monographs. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring reliable quality and supply chain integrity for critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.