Description

tert-Butyl (R)-3-Oxohexahydroimidazo[1,5-A]Pyrazine-7(1H)-Carboxylate is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial importance. Its value lies in its role as a key synthon for constructing complex bioactive molecules, particularly in the development of novel therapeutics. This compound is essential for research and production teams in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for API synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other small molecule drugs.
• Peptidomimetic Research: Serves as a constrained scaffold in the design and development of novel peptidomimetics to enhance metabolic stability and bioavailability.
• Drug Discovery & Medicinal Chemistry: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective synthesis routes due to its defined (R)-configuration.
• Contract Manufacturing (CMO/CDMO): Supplied to contract research and manufacturing organizations for cGMP-compliant production of clinical trial materials and commercial APIs.
• Bioconjugation & Probe Development: Potential use in creating chemical probes or bioconjugates for biochemical and diagnostic applications.

Basic Information

Product Name	tert-Butyl (R)-3-Oxohexahydroimidazo[1,5-A]Pyrazine-7(1H)-Carboxylate
CAS No.	1808248-81-8
Molecular Formula	C11H17N3O3
Molecular Weight	239.27 g/mol
Synonyms	(R)-tert-Butyl 3-oxohexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylate; 7-(tert-Butoxycarbonyl)-3-oxohexahydroimidazo[1,5-a]pyrazine-1(5H)-carboxylic Acid tert-Butyl Ester (R-enantiomer); (R)-Boc-3-oxo-hexahydroimidazo[1,5-a]pyrazine-7-carboxylate; tert-Butyl (R)-3-oxo-1,2,3,5,6,7-hexahydroimidazo[1,5-a]pyrazine-7-carboxylate; (R)-3-Oxo-1,2,3,5,6,7-hexahydroimidazo[1,5-a]pyrazine-7-carboxylic Acid tert-Butyl Ester; CAS 1808248-81-8; Chiral Imidazopyrazine Derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl (R)-3-Oxohexahydroimidazo[1,5-A]Pyrazine-7(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to exclude moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.