Description

Acid-Peg3-T-Butyl Ester CAS NO 1807539-06-5 is a specialized bifunctional PEG derivative featuring a carboxylic acid group and a tert-butyl ester-protected terminal. This compound is engineered to serve as a versatile linker and spacer molecule in advanced chemical synthesis. Its primary value lies in enabling controlled conjugation and functionalization in the development of pharmaceuticals, bioconjugates, and sophisticated materials. Key industries that rely on this high-purity intermediate include pharmaceutical R&D, biotech for probe synthesis, and advanced material science.

Application

• Pharmaceutical Linker: Used as a key building block in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a crucial spacer to connect E3 ligase ligands to target protein ligands, optimizing molecular properties.
• Peptide and Protein Modification: Facilitates the site-specific PEGylation of peptides and proteins to enhance solubility, stability, and pharmacokinetic profiles.
• Bioconjugation & Probe Synthesis: Enables the attachment of dyes, labels, or other functional groups to biomolecules for diagnostic and research applications.
• Polymer & Material Science: Acts as a monomer or cross-linking agent in the creation of functionalized, biocompatible hydrogels and smart materials.
• Chemical Biology Tool: Utilized in the development of chemical probes to study protein function and cellular pathways.

Basic Information

Item	Details
Product Name	Acid-Peg3-T-Butyl Ester
CAS No.	1807539-06-5
Molecular Formula	C15H30O7
Molecular Weight	322.40 g/mol
Synonyms	3,6,9-Trioxaundecanedioic acid, 11-(1,1-dimethylethyl) ester; 11-tert-Butyl 3,6,9-trioxaundecanedioate; TEG-acid-t-butyl ester; Carboxy-PEG3-t-butyl ester; 4,7,10-Trioxatridecanedioic acid, 13-tert-butyl ester; Acid-PEG3-t-Butyl Ester; (2-{2-[2-(2-tert-Butoxy-2-oxoethoxy)ethoxy]ethoxy})acetic acid
EINECS	Contact for details

Quality Control

Our Acid-Peg3-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the stringent requirements for research and cGMP-grade applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.