Description

Benzyl-Peg6-Ch2Co2Tbu is a specialized polyethylene glycol (PEG)-based linker molecule featuring a benzyl-protected terminal carboxylic acid. This compound is engineered to provide a versatile and reactive handle for bioconjugation and the synthesis of complex molecular architectures, particularly in pharmaceutical and diagnostic applications. Its primary value lies in its ability to introduce a hydrophilic PEG spacer, which can improve solubility and pharmacokinetic properties, while the tert-butyl ester offers a protected carboxylic acid group for controlled chemical manipulation. This makes it an essential intermediate for researchers and manufacturers in the fields of proteomics, antibody-drug conjugate (ADC) development, and peptide synthesis.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a key building block for constructing cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Peptide and Protein Modification: Used to introduce PEG chains (PEGylation) onto peptides or proteins to enhance stability, reduce immunogenicity, and prolong circulation half-life.
• Small Molecule Prodrug Synthesis: Acts as a spacer to attach targeting moieties or solubilizing groups to active pharmaceutical ingredients (APIs).
• Diagnostic Reagent Development: Employed in the creation of fluorescent or radioactive probes for imaging and detection assays.
• Polymer and Material Science: Functions as a functional monomer or cross-linking agent for creating advanced hydrogels and biocompatible materials.
• Solid-Phase Synthesis: Utilized as a handle on resin for the sequential assembly of complex molecules, allowing for selective deprotection and further coupling.

Basic Information

Product Name	Benzyl-Peg6-Ch2Co2Tbu
CAS No.	1807537-31-0
Molecular Formula	C31H54O11
Molecular Weight	602.75 g/mol
Synonyms	1-{2-[2-(2-{2-[2-(2-Benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-2-tert-butoxycarbonyl-ethane; 2-(Benzyloxy)ethyl 2,5,8,11,14,17-hexaoxanonadecan-19-oate tert-butyl ester; Benzyl-PEG6-CH2COOtBu; Benzyl-PEG6-t-butyl ester; Benzyl hexaethylene glycol t-butyl ester acetic acid; t-Butyl 2-[2-(2-{2-[2-(2-benzyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxyacetate; Benzyl-PEG6-acid t-butyl ester; BOC-PEG6-OBn (context-dependent alias)
EINECS	Contact for details

Quality Control

Our Benzyl-Peg6-Ch2Co2Tbu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and cGMP-grade applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity, identity, and impurity profiles. We adhere to relevant industry standards and our quality protocols are designed to meet the stringent requirements for pharmaceutical intermediates and bioconjugation reagents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.