Description

Bromo-Peg2-Acid CAS NO 1807503-92-9 is a bifunctional polyethylene glycol (PEG) derivative featuring a reactive bromo group and a carboxylic acid terminus, making it a versatile heterobifunctional linker for bioconjugation and materials science. This compound is essential for creating stable, functionalized biomolecules and surfaces with precise control over architecture and properties. It is primarily needed by researchers and manufacturers in pharmaceutical development, proteomics, and advanced polymer synthesis for constructing antibody-drug conjugates (ADCs), peptide modifications, and functional hydrogels.

Application

• Bioconjugation Linker: A key reagent for coupling biomolecules (e.g., peptides, proteins, oligonucleotides) to other entities like drugs, fluorophores, or solid surfaces via its orthogonal bromo and carboxyl groups.
• Antibody-Drug Conjugate (ADC) Payload Attachment: Used to attach cytotoxic payloads to monoclonal antibodies, leveraging the PEG spacer to improve solubility and pharmacokinetics.
• Polymer and Dendrimer Synthesis: Serves as a functional monomer or chain extender for creating PEG-based copolymers with tailored functionalities for drug delivery systems.
• Surface Functionalization: Employed to modify nanoparticles, biosensors, or chromatography media with reactive groups for subsequent biomolecule immobilization.
• Crosslinking Agent: Utilized in the formation of hydrogels or polymer networks where the bromo group and acid can react with different functional groups.
• Proteomics Research: Facilitates the site-specific labeling or crosslinking of proteins for structural studies or interaction analysis.

Basic Information

Product Name	Bromo-Peg2-Acid
CAS No.	1807503-92-9
Molecular Formula	C7H13BrO4
Molecular Weight	241.08 g/mol
Synonyms	2-[2-(2-Bromoethoxy)ethoxy]acetic acid; Bromo-PEG2-acetic acid; 2,5,8-Trioxa-11-azatridecan-13-oic acid, 11-bromo-; Bromodiglycolic acid; Bromo(triethylene glycol)acetic acid; α-Bromo-ω-carboxy triethylene glycol; Bromo-PEG2-COOH; Bromo(trioxatridecan)oic acid
EINECS	Contact for details

Quality Control

Our Bromo-Peg2-Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.