Description

Benzyl-Peg5-Ch2Co2Tbu is a specialized polyethylene glycol (PEG)-based linker compound featuring a benzyl-protected terminal and a tert-butyl ester group. This bifunctional molecule is engineered to provide a stable, hydrophilic spacer arm for bioconjugation and pharmaceutical development applications. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for creating prodrugs, antibody-drug conjugates (ADCs), and functionalized polymers.

Application

• Bioconjugation Linker: Serves as a crucial spacer in the synthesis of antibody-drug conjugates (ADCs) and peptide-drug conjugates, enhancing solubility and pharmacokinetics.
• Prodrug Synthesis: Used to attach therapeutic agents via a cleavable ester linkage, enabling controlled drug release.
• Polymer Functionalization: Acts as a modifier to introduce reactive groups or hydrophilic PEG chains into polymers and surfaces.
• Proteomics Research: Employed as a tool compound for crosslinking or labeling biomolecules in biochemical assays.
• Nanoparticle Coating: Utilized to improve the biocompatibility and stealth properties of nanocarriers in drug delivery systems.
• Solid-Phase Peptide Synthesis (SPPS): Functions as a handle or protecting group strategy during complex peptide assembly.

Basic Information

Product Name	Benzyl-Peg5-Ch2Co2Tbu
CAS No.	1807503-89-4
Molecular Formula	C26H44O9
Molecular Weight	500.63 g/mol
Synonyms	1-Benzyl-3,6,9,12,15-pentaoxaheptadecan-17-oic acid tert-butyl ester; Benzyl-PEG5-t-butyl ester; 2-[2-[2-[2-[2-(Benzyloxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid tert-butyl ester; tert-Butyl 2,5,8,11,14-pentaoxa-17-azaheptadecan-17-oate; Benzyl-PEG5-CH2COOtBu; Benzyl-O-(CH2CH2O)5-CH2COO-tBu; Benzyl tetraethylene glycol monomethyl ether acetate tert-butyl ester; Bn-PEG5-COOtBu
EINECS	Contact for details

Quality Control

Our Benzyl-Peg5-Ch2Co2Tbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.