Description

Trifluoroacetic Acid CAS NO 1803597-05-8 is a specialized fluorinated organic acid and a powerful solvent widely utilized in advanced chemical synthesis. Its unique combination of high acidity and volatility makes it an indispensable reagent for deprotection and cleavage reactions in peptide and oligonucleotide synthesis. This high-purity compound is essential for pharmaceutical development, agrochemical manufacturing, and materials science research, where precise reaction control and high yields are critical.

Application

• Peptide Synthesis: As a key cleavage and deprotection reagent in solid-phase peptide synthesis (SPPS).
• Oligonucleotide Manufacturing: Used in the deprotection of phosphate and base protecting groups during DNA/RNA synthesis.
• Pharmaceutical Intermediates: A catalyst and solvent in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Analytical Chemistry: Employed as a mobile phase modifier in HPLC for the separation of polar compounds and biomolecules.
• Polymer Chemistry: Acts as a solvent and catalyst in polymerization reactions and for the production of specialty fluoropolymers.
• Agrochemical Synthesis: A reagent in the production of fluorinated pesticides and herbicides.
• Organic Synthesis: A versatile reagent for esterifications, acylations, and as a strong acid catalyst in various transformations.

Basic Information

Product Name	Trifluoroacetic Acid
CAS No.	1803597-05-8
Molecular Formula	C2HF3O2
Molecular Weight	114.02 g/mol
Synonyms	Trifluoroethanoic Acid; TFA; Perfluoroacetic Acid; 2,2,2-Trifluoroacetic Acid; CF3COOH; Trifluoroacetic Acid Anhydride (when relevant); Kyselina trifluoroctova
EINECS	Contact for details

Quality Control

Our Trifluoroacetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay, impurity profiling, and verification of physical properties, to ensure it meets the stringent requirements of pharmaceutical and research applications. A Certificate of Analysis (COA) is provided with every shipment, detailing purity, assay results, and critical impurity limits.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile and strong acid/organic solvent nature, containers must be kept tightly sealed to prevent moisture absorption and evaporation. Recommended storage temperature is 2-25°C.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms
Assay (GC)	≥ 99.5%
Water Content (KF)	≤ 0.05%
Residue on Ignition	≤ 0.005%
Chloride (Cl)	≤ 10 ppm
Sulfate (SO4)	≤ 10 ppm
Heavy Metals (as Pb)	≤ 5 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.