Description

1-(Azetidin-3-Yl)-4-Methylpiperazine 3Hcl is a high-purity, advanced pharmaceutical intermediate featuring a unique heterocyclic structure combining azetidine and methylpiperazine moieties. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of targeted therapeutics, particularly in oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel small-molecule drug candidates.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• API Synthesis: Incorporated into the synthesis of complex target molecules for preclinical and clinical trials.
• Oncology Drug Discovery: Serves as a building block for potential kinase inhibitors and other targeted cancer therapies.
• CNS-Active Compound Development: Utilized in the research of modulators for neurological and psychiatric disorders.
• Chemical Biology Probes: Employed in the design and synthesis of tool compounds for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP conditions.

Basic Information

Product Name	1-(Azetidin-3-Yl)-4-Methylpiperazine 3Hcl
CAS No.	1803590-57-9
Molecular Formula	C8H18N3•3HCl
Molecular Weight	279.62 g/mol (as free base: 155.25 g/mol)
Synonyms	1-(Azetidin-3-yl)-4-methylpiperazine trihydrochloride; 4-Methyl-1-(azetidin-3-yl)piperazine trihydrochloride; 3-(4-Methylpiperazin-1-yl)azetidine trihydrochloride; Azetidine, 3-(4-methyl-1-piperazinyl)-, trihydrochloride; 1803590-57-9; 1-Azetidin-3-yl-4-methyl-piperazine 3HCl
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for advanced pharmaceutical intermediates. Each batch is characterized and controlled using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) are available upon request, detailing all critical quality attributes. We adhere to a quality management system suitable for supplying materials for research and non-GMP development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to minimize exposure to moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.