Description

Trifluoroacetic Acid is a highly versatile and potent fluorinated organic acid, essential for a wide range of synthetic and analytical processes. Its strong acidity and excellent solvating properties make it a critical reagent for peptide synthesis, pharmaceutical manufacturing, and as a solvent for NMR spectroscopy. This compound is indispensable for industries requiring high-purity intermediates and robust reaction media, including pharmaceuticals, agrochemicals, and advanced materials.

Application

• Peptide Synthesis & Protecting Group Removal: A key reagent for cleaving protecting groups (e.g., Boc, t-butyl esters) in solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing the trifluoromethyl group to enhance metabolic stability and lipophilicity.
• NMR Spectroscopy Solvent: Serves as a deuterated solvent (TFA-d) for nuclear magnetic resonance analysis due to its excellent solubility properties and minimal interference.
• HPLC Mobile Phase Modifier: Employed as an ion-pairing agent and pH modifier in reverse-phase high-performance liquid chromatography to improve peak shape and separation.
• Organic Synthesis & Catalysis: Acts as a strong acid catalyst and solvent in various organic transformations, including esterifications, rearrangements, and cyclizations.
• Polymer & Resin Manufacturing: Utilized in the production of specialty polymers and as an etching or cleaning agent in electronic materials processing.

Basic Information

Product Name	Trifluoroacetic Acid
CAS No.	1788041-58-6
Molecular Formula	C2HF3O2
Molecular Weight	114.02 g/mol
Synonyms	Trifluoroethanoic Acid; TFA; Perfluoroacetic Acid; 2,2,2-Trifluoroacetic Acid; CF3COOH; Trifluoroacetic Acid Anhydride (precursor); Kyselina trifluoroctova
EINECS	Contact for details

Quality Control

Our Trifluoroacetic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as assay, water content, and impurity profiles. Our quality protocols are designed to meet the stringent requirements of pharmaceutical (GMP), analytical, and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat and incompatible materials. Due to its hygroscopic and highly volatile nature, containers should be kept tightly sealed and under an inert atmosphere if necessary to maintain purity. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms
Assay (GC)	≥ 99.5%
Water Content (KF)	≤ 0.05%
Residue on Evaporation	≤ 0.005%
Chloride (Cl)	≤ 10 ppm
Sulfate (SO4)	≤ 10 ppm
Heavy Metals (as Pb)	≤ 5 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.