Description

tert-Butyl 4-(1-Ethoxycyclopropanecarbonyl)piperazine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core with cyclopropane and tert-butoxycarbonyl (Boc) protecting groups. This compound matters for its critical role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) and other therapeutic areas. Pharmaceutical R&D teams and fine chemical manufacturers need this building block for its versatility in constructing novel molecular architectures, enabling the development of new drug candidates with improved efficacy and safety profiles.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, particularly in medicinal chemistry.
• API Synthesis: Used in the research and development of Active Pharmaceutical Ingredients (APIs) for potential CNS, antiviral, or anti-infective therapies.
• Protease Inhibitor Research: Serves as a precursor in the development of protease inhibitors due to its piperazine and carbonyl functionalities.
• Chemical Biology & Proteomics: Employed in the design and synthesis of chemical probes for studying biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 4-(1-Ethoxycyclopropanecarbonyl)piperazine-1-carboxylate
CAS No.	1788041-42-8
Molecular Formula	C15H26N2O4
Molecular Weight	298.38 g/mol
Synonyms	1-Boc-4-(1-ethoxycyclopropanecarbonyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(1-ethoxycyclopropanecarbonyl)piperazine; 4-(1-Ethoxycyclopropanecarbonyl)piperazine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(1-ethoxycyclopropanecarbonyl)piperazine-1-carboxylate; 1-Ethoxycyclopropanecarboxylic acid 4-(tert-butoxycarbonyl)piperazin-1-yl ester; BOC-Piperazine Cyclopropane Ester; 1788041-42-8
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(1-Ethoxycyclopropanecarbonyl)piperazine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards expected for pharmaceutical intermediates in both research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.