Description

(S)-6-Fluoro-2-(Piperidin-3-Yl)Isoindolin-1-One Hydrochloride is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of targeted small molecule therapeutics. It is primarily needed by pharmaceutical R&D departments, contract research and manufacturing organizations (CROs/CMOs), and academic research institutions focused on developing novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its defined stereochemistry and functionalized isoindolinone-piperidine scaffold.
• API Synthesis: Serves as a critical building block in the multi-step synthesis of potential active pharmaceutical ingredients (APIs) requiring this specific fluorinated chiral moiety.
• Chemical Biology Probes: Can be utilized in the development of chemical probes for studying biological pathways and target validation.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for clinical trial material production.
• Custom Synthesis: A starting material for the custom synthesis of more complex, proprietary molecules for client-specific drug discovery projects.

Basic Information

Product Name	(S)-6-Fluoro-2-(Piperidin-3-Yl)Isoindolin-1-One Hydrochloride
CAS No.	1787331-47-8
Molecular Formula	C13H16ClFN2O
Molecular Weight	270.73 g/mol
Synonyms	(3S)-6-Fluoro-2-(3-piperidinyl)-1H-isoindol-1-one hydrochloride; (S)-6-Fluoro-2-(3-piperidyl)isoindolin-1-one HCl; 1H-Isoindol-1-one, 6-fluoro-2-(3-piperidinyl)-, hydrochloride, (3S)-; (S)-6-Fluoro-2-(piperidin-3-yl)isoindolin-1-one hydrochloride; 1787331-47-8; (S)-6-Fluoro-2-(3-piperidinyl)isoindolin-1-one hydrochloride; (S)-6-Fluoro-2-(piperidin-3-yl)-2,3-dihydro-1H-isoindol-1-one hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-6-Fluoro-2-(Piperidin-3-Yl)Isoindolin-1-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research-grade and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.