Description

2-Methyl-1-(Oxetan-3-Yl)Piperazine Bis(2,2,2-Trifluoroacetate) is a high-purity, non-racemic synthetic building block and intermediate of significant interest in modern pharmaceutical research and development. Its value lies in its unique piperazine-oxetane hybrid structure, which is increasingly utilized to modulate the physicochemical and pharmacokinetic properties of drug candidates. This compound is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to introduce favorable properties like improved solubility and metabolic stability.
• Process Chemistry: Serves as a starting material or advanced intermediate in the development of scalable, GMP-compliant synthetic routes for clinical and commercial manufacturing.
• Ligand Synthesis: Employed in the preparation of sophisticated ligands for catalysis or as a core structure in chemical biology probes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.
• Academic Research: Utilized in university and institutional labs for methodological development and the exploration of new chemical entities.

Basic Information

Product Name	2-Methyl-1-(Oxetan-3-Yl)Piperazine Bis(2,2,2-Trifluoroacetate)
CAS No.	1776946-72-5
Molecular Formula	C13H20F6N2O5
Molecular Weight	398.31 g/mol
Synonyms	2-Methyl-1-(oxetan-3-yl)piperazine ditrifluoroacetate; 1-(Oxetan-3-yl)-2-methylpiperazine bis(trifluoroacetate); 2-Methyl-1-(3-oxetanyl)piperazine bis(2,2,2-trifluoroacetate); (R/S)-2-Methyl-1-(oxetan-3-yl)piperazine bis(TFA salt); 2-Methyl-1-(oxetane-3-yl)piperazine di(trifluoroacetic acid) salt; 1776946-72-5; UNII-Contact for details
EINECS	Contact for details

Quality Control

Our 2-Methyl-1-(Oxetan-3-Yl)Piperazine Bis(2,2,2-Trifluoroacetate) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.